目的 研究独子藤(Celastrus monospermus Roxb.)根皮的化学成分。方法 采用硅胶、反相硅胶和凝胶等柱色谱方法进行分离纯化,通过化合物的波谱学数据鉴定其结构。结果 从独子藤根皮中分离得到23个化合物,分别为β-谷甾醇棕榈酸酯(1),木栓酮(2),齐墩果烯(3),Δ5,22-胆甾烯醇(4),β-谷甾醇(5),3,22-二氧代-20-蒲公英烯(6),3,12-二氧代木栓烷(7), 28-羟基木栓酮(8),11β-羟基木栓酮(9),12α-羟基木栓酮(10),扁蒴藤素(11),30-羟基木栓酮(12),3-氧代-29-木栓烷酸(13),大子五层龙酸(14),雷公藤红素(15),3β,21β-二羟基-30-降-木栓烷-20(29)-烯-27-酸(16),3β,22α-二羟基齐墩果烷-12-烯-29-酸(17),wilforol A(18),直楔草酸(19),对羟基苯甲酸(20),3-氧代-2β-羟基木栓烷-29-酸(21),21-氧代-2α,3α,22β-三羟基-29-降-木栓烷-24,2β-内酯(22)和胡萝卜苷(23)。结论 化合物1,6,13~14,16~ 22等11个化合物为首次从本植物中分离得到,16, 20~22等4个化合物为首次从本属植物中分离得到。
Abstract
OBJECTIVE To study the chemical constituents from the root bark of Celastrus monospermus Roxb. METHODS The compounds were isolate and purified by repeated column chromatography on silica gel, ODS and Sephadex LH-20, and the chemical structures of compounds were determined by spectral data analyses. RESULTS Twenty-three compounds were isolated from this plant, which were identified as β-sitosterol palmitate (1), friedelan-3-one (2), 3β-hydroxyolean-12-en (3), 3β-hydroxylcholest-5,22-dien (4), β-sitosterol (5), 3,22-dioxo-20-taraxastene (6), 3,12-dioxofriedelane (7), 3-oxo-28-hydroxyfriedelane (8), 3-oxo-11β-hydroxyfriedelane (9), 3-oxo-12α-hydroxyfriedelane (10), pristimerin(11), 3-oxo-30-hydroxyfriedelane (12), 3-oxo-29-friedelanoic acid (13), salaspermic acid (14), celastrol (15), 3β, 21β-dihydroxy-30-nor-friedelan-20(29)-en-27-oic acid (16), 3β, 22α-dihydroxy-olean-12-en-29-oic acid (17), wilforol A (18), orthosphenic acid (19), p-hydroxybenzoic acid (20), 3-oxo-2β-hydroxyfriedelan-29-oic acid (21), 21-oxo-2α,3α,22β-trihydroxy-29-nor-friedelan-24,2β-lactone (22)and daucosterol (23). CONCLUSION Compounds 1,6, 13-14,16-22 are obtained from this plant for the first time, and compounds 16, 20-22 are isolated from the genus Celastrus for the first time.
关键词
独子藤 /
根皮 /
化学成分 /
木栓烷型三萜
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Key words
Celastrus monospermus /
root bark /
chemical constituent /
friedelane
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参考文献
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脚注
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基金
广东省中医药局面上科研项目资助(20171154)
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